Basic Information
VIS ID
TVIS10017041
Fusion event
HBV-chrX integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1
End
39
Integrated sequence
ATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAG
Host Sequence
Chromosome
chrX
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
129330421/130196447 (Hg38)
End
129330513/130196539 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/8825394; hsa-mir-105-1/Downstream/3972839;
Nearest TSS
ENST00000429181/Upstream/24798; ENST00000467346/Downstream/72344;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/23994, chrX-CpG: 58/Downstream/71945
Nearby gene
ZNF280C(+6252) ;
Upstream sequence
ATTTTATTTGTAAGTCCGATTCAATATGCTCAAGCACACATCATTAAATGTTTCCTTTTAATTTTGAGTAGCAAATATCTTCATTTCAGTAGCACCTACA
Downstream sequence
TGCCACATGTAATTGAAGCACTGTGATAAGATGTCATCCACCCGACAGTTTGAAGGAATGTACTTCAAGACCTGGGAATTATAAGCCAAAGTTATGAATA
Target sequence
ATTCCGTAGTAGTTTTCAATAAGGCAGTGTCATTTCGTAGTCCTTAGACAGAAAAAGCCAGAGCTACGCTCATTTCCGACATTAGAGAATTA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate