Basic Information
VIS ID
TVIS10017044
Fusion event
HBV-chr11 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1819
End
1910
Integrated sequence
AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATC
Host Sequence
Chromosome
chr11
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
29207683/29186136 (Hg38)
End
29207783/29186236 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-210/Upstream/708588; hsa-let-7a-2/Downstream/5755601;
Nearest TSS
ENST00000527297/Upstream/26180; ENST00000527727/Downstream/164113;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1075462, chr11-CpG: 25/Downstream/829889
Upstream sequence
acagagtgagactttgtctcaaaaaaaaaaaaaaaaaaaaaTTCCTAGAACTAAGGAAGGGTCAAAAAaaactatggcctacaggacaaatctggcccat
Downstream sequence
cacagttcctgtgtgcctttctaagcaatttatttataataactcattcaatcattatacaaacaatgcggagatcaatattatttctatcttcatttta
Target sequence
TATTTTCCAAGGGTCTTAGGGGGAAAAGTGGGTACATCATCATTTTGTAGGGCAATAAAGTTGGGAAAATCATTTTAAAAACCAGTTaacatttatatac
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate