Fusion event
HBV-chr11 integration
Detection method
Capture-NGS platform
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
CGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGT
End
29207893/29186346 (Hg38)
Nearest miRNA
hsa-mir-210/Upstream/708701; hsa-let-7a-2/Downstream/5755491;
Upstream sequence
TGGGAGACTAGAATAATATTCCTCTCCATACAGAGGAACTCTTAAAAAAAAAAAAATCTGTAAGACCTAGAAACCTGTGAACCCACCTTCTGTGTAATCC
Downstream sequence
aactgaggcatagagaagataagaaatttgcctaaattcacaaagtattaaatatattgtatagctagtgttctaattgaggtagtatgactccagggCA
Target sequence
tgcctttctaagcaatttatttataataactcattcaatcattatacaaacaatgcggagatcaatattatttctatcttcattttataggtaagga
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.