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VISDB
Viral Integration Site DataBase
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TVIS10017046
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017046
Fusion event
HBV-KMT2B integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1757
End
1848
Integrated sequence
GGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTT
Host Sequence
Chromosome
chr19
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
36213700/35722798 (Hg38)
End
36213800/35722898 (Hg38)
Location type
Intron
Fragile sites / regions
FRA19A
Target gene
KMT2B
miRNAs that regulate target gene
hsa-mir-7515
;
hsa-mir-302a-5p
;
hsa-mir-3154
;
hsa-mir-6782-3p
;
hsa-mir-519c-3p
;
hsa-mir-519b-3p
;
hsa-mir-519a-3p
;
hsa-mir-5692a
;
hsa-mir-548t-5p
;
hsa-mir-548az-5p
;
hsa-mir-526b-3p
;
hsa-mir-519d-3p
;
hsa-mir-93-5p
;
hsa-mir-20a-5p
;
hsa-mir-17-5p
;
hsa-mir-106b-5p
;
hsa-mir-106a-5p
;
hsa-mir-20b-5p
;
hsa-mir-153-3p
;
hsa-mir-1224-3p
;
hsa-mir-1294
;
hsa-mir-1914-3p
;
hsa-mir-214-3p
;
hsa-mir-31-5p
;
hsa-mir-3184-5p
;
hsa-mir-3619-5p
;
hsa-mir-3689d
;
hsa-mir-423-5p
;
hsa-mir-4316
;
hsa-mir-4426
;
hsa-mir-4440
;
hsa-mir-4459
;
hsa-mir-4647
;
hsa-mir-4662b
;
hsa-mir-4688
;
hsa-mir-4722-5p
;
hsa-mir-5194
;
hsa-mir-6085
;
hsa-mir-6165
;
hsa-mir-6734-5p
;
hsa-mir-6738-5p
;
hsa-mir-6743-5p
;
hsa-mir-6789-5p
;
hsa-mir-6813-5p
;
hsa-mir-6851-5p
;
hsa-mir-761
;
hsa-mir-7704
;
hsa-mir-885-3p
Nearest miRNA
hsa-mir-10395/Upstream/377171; hsa-let-7e/Downstream/3686725;
Nearest TSS
ENST00000633603/Upstream/1896;
ENST00000592092/Downstream/10360;
Nearest CpG islands
None/Target,
chr19-CpG: 112/Upstream/2774
,
chr19-CpG: 24/Downstream/828
Upstream sequence
aatagctgggattacaggagtgcgccaccacgtccagctaatttttgtatttttagtagagatggtattttaccatgttgatcaggctggtctcaaactc
Downstream sequence
GAGAAAGCGAGAGCCAGGTTGTGGGAAAGCAGGGAAGTGAGGTAGAAGCCTGGTGGCTTTGTGGCTCCATCCCCTCCTCCCTGCCTGCTGCAATAGATAC
Target sequence
GAGGGAGCCAAGTCAGGTGCTCAGGGGTTAGGTGGCAAGTGGGCTGGAGTGCTAGGTCCTAGAGCAACTTCATTTGGGGGCACCAGGAACCTGGCGCTGT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Sample Information
×
Sample name
M24
Sample type
Tumor
Gender
Male
CpG Island Information
×
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