Basic Information
VIS ID
TVIS10017049
Fusion event
HBV-chrX integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2391
End
2484
Integrated sequence
CGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTT
Host Sequence
Chromosome
chrX
Cytoband
q23
Reference genome
GRCh37/hg19
Start
115815118/116681150 (Hg38)
End
115815220/116681252 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-let-7f-2/Upstream/1857586; hsa-mir-105-1/Downstream/1705142;
Nearest TSS
ENST00000429181/Upstream/218147; ENST00000493448/Downstream/12936;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/712086, chrX-CpG: 74/Downstream/1435018
Nearby gene
LOC100422432(-2877) ; LOC100462652(+7680) ;
Upstream sequence
tgaggcatgttccttcaatacctagtttattgagagtttttaacataaagggatgttacattttatcaaaggccttttctgtatctcttgagataatcat
Downstream sequence
atgctgctatggatatttgtgtacacttttttgtgtagacttatgttttcaattatcttggttatatacctaggagagaaatcgccgggtcacatggtaa
Target sequence
ttatggctgaataacatttaatcatatagatagatcatattttacttacacatttatcacctgatgacatttggcttggttctaccttggctattatgaata
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate