Basic Information
VIS ID
TVIS10017051
Fusion event
HBV-chr17 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
337
End
426
Integrated sequence
CACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCC
Host Sequence
Chromosome
chr17
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
22251311/22751984 (Hg38)
End
22251408/22752081 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1180/Upstream/3407410; hsa-mir-10226/Downstream/4541829;
Nearest TSS
ENST00000595228/Upstream/59150; ENST00000583786/Downstream/4247844;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/59302, chr17-CpG: 114/Downstream/3978947
Upstream sequence
TTTATTGTACTCTGTAATTCTATTTCTGTTCAAATTCCATGGAATCCTCTAGGGCACCCTGGGATTGTGAATTAGTGTGAATGAATGTAAATAGCTTTAG
Downstream sequence
ctggaatctgcaaggggacatgcagacctctttgaaggtttcgttggaaacagaatcatcttcacataaaaattacacagaagcattctcaggaactcct
Target sequence
agacagaagcattctcagaaacttttctgtgatgactgcattcaactcacagagttgaacactccttttgagagcgcagttttgaaactctctttct
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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