Basic Information
VIS ID
TVIS10017054
Fusion event
HBV-LOC105371597 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1696
End
1785
Integrated sequence
CTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGT
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
21794211/22267605 (Hg38)
End
21794309/22267703 (Hg38)
Location type
Intronic
Target gene
LOC105371597
Nearest miRNA
hsa-mir-1180/Upstream/2923031; hsa-mir-10226/Downstream/5026207;
Nearest TSS
ENST00000595228/Upstream/1180; ENST00000577956/Downstream/17879;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/50084, chr17-CpG: 27/Downstream/167671
Upstream sequence
taaccgtggatcaaaaatattcaggaaaaaaaaatggaaaatatacaagaaaaaataatacaaatttaaaaaccaacacagcacaagaactatttacaca
Downstream sequence
GAGGACGATCCTCATGGGAATCCATTACATGAGTGTTTTCTTCTAAACGCTGTCACGTTTTAATGACTGGCAGCTGTTATAATTTTAAAACCGTAAATTC
Target sequence
ACTTGCCTCTTCTTTTGCTGACTTCCATGTTCCTCATCGGCCTAGGGTTTCCTGGGGCTGGCTCAACGTCTTACACACTAAATGTTTCACAGTTCACA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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