VISDB Viral Integration Site DataBase

VIS ID

TVIS10017056

Fusion event

HBV-REST integration

Validated

No

Detection method

Capture-NGS platform

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2019

PubMed ID

Virus name

HBV

Subtype

B

Reference genome

Start

1886

End

1977

Integrated sequence

TGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTT

Chromosome

chr4

Cytoband

q12

Reference genome

Start

End

57777036/56910870 (Hg38)

Location type

Promoter

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-9-5p ; hsa-mir-21-5p ; hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-302a-3p ; hsa-mir-302b-3p ; hsa-mir-302c-3p ; hsa-mir-302d-3p ; hsa-mir-372-3p ; hsa-mir-373-3p ; hsa-mir-20b-5p ; hsa-mir-520e ; hsa-mir-520a-3p ; hsa-mir-526b-3p ; hsa-mir-520b ; hsa-mir-520c-3p ; hsa-mir-519d-3p ; hsa-mir-520d-3p ; hsa-mir-302e ; hsa-mir-4690-5p ; hsa-mir-4742-5p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-29c-3p ; hsa-mir-6835-3p ; hsa-mir-142-5p ; hsa-mir-190a-3p ; hsa-mir-4693-5p ; hsa-mir-4796-3p ; hsa-mir-5590-3p ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-620 ; hsa-mir-670-5p ; hsa-mir-548l ; hsa-mir-1270 ; hsa-mir-4319 ; hsa-mir-4324 ; hsa-mir-4251 ; hsa-mir-4531 ; hsa-mir-4683 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-105-5p ; hsa-mir-4719 ; hsa-mir-7853-5p ; hsa-mir-562 ; hsa-mir-646 ; hsa-mir-548n ; hsa-mir-4323 ; hsa-mir-3653-3p ; hsa-mir-4660 ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-4802-3p ; hsa-mir-4422 ; hsa-mir-4752 ; hsa-mir-6833-5p ; hsa-mir-7847-3p ; hsa-mir-539-5p ; hsa-mir-4638-3p ; hsa-mir-4732-3p ; hsa-mir-345-3p ; hsa-mir-548c-3p ; hsa-mir-378b ; hsa-mir-378a-3p ; hsa-mir-378f ; hsa-mir-378h ; hsa-mir-378i ; hsa-mir-378e ; hsa-mir-378c ; hsa-mir-422a ; hsa-mir-378d ; hsa-mir-9-3p ; hsa-mir-5703 ; hsa-mir-4434 ; hsa-mir-4516 ; hsa-mir-494-3p ; hsa-mir-7844-5p ; hsa-mir-6083 ; hsa-mir-676-5p ; hsa-mir-302a-5p ; hsa-mir-421 ; hsa-mir-7159-5p ; hsa-mir-138-2-3p ; hsa-mir-892c-3p ; hsa-mir-4676-3p ; hsa-mir-452-5p ; hsa-mir-505-3p ; hsa-mir-4668-5p ; hsa-mir-6769a-3p ; hsa-mir-3943 ; hsa-mir-410-3p

Nearest miRNA

hsa-mir-12113/Upstream/4198023; hsa-mir-1243/Downstream/4011749;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/1334, chr4-CpG: 109/Downstream/65598

Upstream sequence

AGGTTTGTTATGGGCAAATGGATTAACACtataaataatttattttttgtagtataaattattttGAAGCAAAGAGTATCATCCATTATTCCTTTCACTT

Downstream sequence

CGGTTGGGGATAACAACTTTTCAGATAGTGAAGAAGGAGAAGGACTTGAAGAGTCTGCTGATATAAAAGGTGAACCTCATGGACTGGAAAACATGGAACT

Target sequence

CAGCTTATTATGCTGGCAAATGTGGCCTTAACTGGGGAAGTAAATGGCAGCTGCTGTGATTACCTGGTCGGTGAAGAAAGACAGATGGCAGAACTGATGC