PRPF31 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017057
Fusion event
HBV-PRPF31 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1836
End
1885
Integrated sequence
CTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCT
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
58024239/57158073 (Hg38)
End
58024329/57158163 (Hg38)
Location type
Intron
Fragile sites / regions
FRA4B
Target gene
PRPF31
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-12113/Upstream/4445326; hsa-mir-1243/Downstream/3764456;
Nearest TSS
ENST00000502981/Upstream/3496; ENST00000515865/Downstream/20982;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/47323, chr4-CpG: 58/Downstream/5512
Upstream sequence
ttccattccactccactccactccattccattccattccactcgggttgattccattccattccattccaatccattccattccattccattccattcca
Downstream sequence
AATGTGATGGATCCTGGCATCATTCCACGCAGACGCCAGGTAGGTGTCCCTGTCCACAGCTCTCTGAGCTCCTGGGATAATTTCAAAACAGCAGAGAGTG
Target sequence
CTCTTAAAGAAAATTTGAAGGTGAGCAGGCGGTGGGCAGAGGATCTGAAGCAGCTGCAAGGGCCTCACATGAGTTTGGAAATGTCTTCCT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate