PRPF31 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017058
Fusion event
HBV-PRPF31 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
207
End
299
Integrated sequence
GGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGT
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
58030365/57164199 (Hg38)
End
58030462/57164296 (Hg38)
Location type
Intron
Fragile sites / regions
FRA4B
Target gene
PRPF31
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-12113/Upstream/4451452; hsa-mir-1243/Downstream/3758323;
Nearest TSS
ENST00000502981/Upstream/9622; ENST00000515865/Downstream/14849;
Nearest CpG islands
chr4-CpG: 58/Target, None/Upstream, None/Downstream
Upstream sequence
ttccattccattccattccattccgttctgttccgttccgttccgttccattccattccattccattccattgcattccactggggttgattccattcca
Downstream sequence
GGAGGCATTGCCTCTTCCCGACTATGGGGGATACTGCACGGGGCTCCCGATGGCCTCTTCCACGCCTGGCCCTTCACTTCTTGAAGCTCACCCTTTTCTT
Target sequence
TCACACACTGCGCAGGAGCCGGCGCGGGAAGGCGGCGGGGCTGTCCTTCCCGGTCAGCGTCCTACGCGTGACCTTGGGACCCGCAAATGTCTGCGCC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate