Basic Information
VIS ID
TVIS10017059
Fusion event
HBV-LOC105377732 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2750
End
2844
Integrated sequence
TACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTA
Host Sequence
Chromosome
chr5
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
172831836/173404833 (Hg38)
End
172831939/173404936 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
LOC105377732
Nearest miRNA
hsa-mir-10397/Upstream/57297; hsa-mir-1229/Downstream/1346798;
Nearest TSS
ENST00000502646/Upstream/75330; ENST00000523205/Downstream/9099;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/74738, chr5-CpG: 56/Downstream/211184
Upstream sequence
CTCGCGCCGCGAGGAGAgggcggggccgcggaaaggaaggggaggggctgggagggcccggagggggctgggccggggacccgggaggggtcgggacggg
Downstream sequence
tgtcatagatagctcttattattttgaaatacgtcccatcaatacctaatttcttgagagtttttagcatgaagggttgttgaattttgtcaaaggcttt
Target sequence
gtgttgaataggagcggtgagagagggcatccctgtcttgtgccagttttcaaagggaatgcttccagtttttgcccattcagtatgatattggctgtgggtt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate