Basic Information
VIS ID
TVIS10017060
Fusion event
HBV-chr6 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
3130
End
3191
Integrated sequence
TACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr6
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
16920350/16920119 (Hg38)
End
16920450/16920219 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-3691/Upstream/778495; hsa-mir-10398/Downstream/1651565;
Nearest TSS
ENST00000381078/Upstream/155773; ENST00000354384/Downstream/182039;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/157365, chr6-CpG: 34/Downstream/181859
Upstream sequence
AACAGGAATTAAACATTTTAAAATGTTTATAACAAAGAAACTTTAATCTTACAGACTTAAATGTTGGAATATCATTATTTTAATTTGGTTTAAAAAATTG
Downstream sequence
TATGGTAATTTGAGTTAACAAATCTGAAAGTAAAGAAGGAAGAACTGTTGTAACTATTATTCTCATTTCTCAACCAGAAGTGCAACTAGTGAGAATATTA
Target sequence
ttaaggctggttgtggggagaaaaacaagtataaaaagtccctcaattcaaaaaacttataatctGCAAATTTATAAGCAAATACCTATAAAATAAAAGC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate