Basic Information
VIS ID
TVIS10017061
Fusion event
HBV-chr8 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
62
End
151
Integrated sequence
TGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCT
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
36052210/36194692 (Hg38)
End
36052308/36194790 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/6237344; hsa-mir-10400/Downstream/5076258;
Nearest TSS
ENST00000518652/Upstream/99646; ENST00000522417/Downstream/584374;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/958099, chr8-CpG: 351/Downstream/1499636
Nearby gene
LOC105379370(-1750) ; LOC105379371(+351) ;
Upstream sequence
atacatataaaatggaatattattcagcattgaaaaagtaaaattttgacccatgtacaacatggatgaatcttaaggacattatgctaagtgaaataaa
Downstream sequence
TTGGCTTTTCCCAGTGCATAGGATCTAGCTGTTCCTCTAGCCTTGAAGCCTGTGGTTATCTCTCAAGAGTATTTCATCCTAGATTTTACTCACAGAACCT
Target sequence
GTTCATGCAACTTTAATCTTCTGGCACTCTCACCCTTTCCTTAGCTTTGGCCTCTACCCTCACTTTGGAATTGAGCATGGATCTTAAGTATTTGAACC
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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