NADK _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017062
Fusion event
HBV-NADK integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
792
End
879
Integrated sequence
TTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAAATTTTAT
Host Sequence
Chromosome
chr1
Cytoband
p36.33
Reference genome
GRCh37/hg19
Start
1709148/1777709 (Hg38)
End
1709245/1777806 (Hg38)
Location type
Intron
Fragile sites / regions
FRA1A
Target gene
NADK
miRNAs that regulate target gene
hsa-mir-425-5p ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-12136/Upstream/438001; hsa-mir-101-1/Downstream/1350169;
Nearest TSS
ENST00000473358/Upstream/19134; ENST00000412228/Downstream/613;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/17085, chr1-CpG: 151/Downstream/149
Upstream sequence
CAAGAAATGGGAACGTTTTCTACATCCAGAAAAATGTCGCGACAACCGTTATGAAATCTAAGGGCTCAAGGAGGATTTAGCAATAAATTGAGAGCAGAGT
Downstream sequence
AGTACTGGGCACTAAATCAGAGATGTGTTTTTAGAGAATTCCATGCCAATACTGCTGTATAGAATCTTTTATTCATACTTTCCCACTAGGTTTGGGCCCC
Target sequence
ACGACGACCTAGAGCTCAAGGCCGGTGCTGACATCTGACCTACTGGATGGCAGCCGCCTGTAGGAACATCACCATAGACTATTGGAATTTTCTGGCA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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