Basic Information
VIS ID
TVIS10017066
Fusion event
HBV-chr16 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1714
End
1804
Integrated sequence
GACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCG
Host Sequence
Chromosome
chr16
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
72220524/72186625 (Hg38)
End
72220616/72186717 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/2156203; hsa-mir-11401/Downstream/4682219;
Nearest TSS
ENST00000527434/Upstream/9747; ENST00000564508/Downstream/38427;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/93183, chr16-CpG: 51/Downstream/477927
Upstream sequence
cagcctccaaagtagctgggattacaggtgcctgccaccacgcctggctaattttgtatttttagttgagacagggttttaccatgtcggccaggctggt
Downstream sequence
GTGATAGGTGTGAAATCTATTTCTTTAATTTGTCACTGTAACAGTATATTATATCCAAATATATAAACACATTTATAGAAGTTTATTAAGCAGCAATTAA
Target sequence
AGACAGAGAGAGGAAGCAGAGCAGAAGGCCTAGAAAGCTAGACAGGAGTTAGGAGATGACTCTTTTCAAATAAAAATAGCCAGTTGAGCAGA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate