Fusion event
HBV-chr16 integration
Detection method
Capture-NGS platform
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
TGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCA
Nearest CpG islands
None/Target, None/Upstream, None/Downstream
Upstream sequence
AGAGGCAACAGGGAGCCATGAAGGTTTTCGAGCTGGGGAGAGACACATCAACAATTGCTTCGTGTACATTAGCCTGACCTCTGTGTGTGGGAGACCGAAT
Downstream sequence
attcaatgactccattggagtccattcaacaattccattcgactccattcgatgattccattcgattccatttgatgattccattcgagtccatttaatc
Target sequence
tccattcgatgatttcattcgagtacatccaatgattccattcgagtacatttgatgattccatttgattccatttgataatgattctactagagtcc
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.