Basic Information
VIS ID
TVIS10017068
Fusion event
HBV-chr17 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2864
End
2958
Integrated sequence
TCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAA
Host Sequence
Chromosome
chr17
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
63521190/65525072 (Hg38)
End
63521289/65525171 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10226/Upstream/702970; hsa-mir-1250/Downstream/1261901;
Nearest TSS
ENST00000595228/Upstream/67531; ENST00000583775/Downstream/11511;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/401484, chr17-CpG: 66/Downstream/11666
Nearby gene
AXIN2(+3491) ;
Nearest cancer related gene
AXIN2(TSG, +3491) ;
Upstream sequence
GAGGGTCCATGGATGAAGGTCTGGAGGTAAAGTCTCCTTGGTCCCATCCTGACTACTCCCCAAATGACCATGAGAAAATCCATCGCTTTTGCAAGAATCA
Downstream sequence
gcacaggattgagaggccgaggtgggggaatcacctgaggtcaggagttcaagaccagcctggccaacatggtgaaaccccgtctctactaaaatacaaa
Target sequence
ttggcccccaaagtgctaggataacCCAATCTTTaaacgggttaaagactttaatagacatttctcggccgggggcggtggctcatgcctgtaatccta
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate