Basic Information
VIS ID
TVIS10017069
Fusion event
HBV-chr12 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1781
End
1826
Integrated sequence
GCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT
Host Sequence
Chromosome
chr12
Cytoband
q15
Reference genome
GRCh37/hg19
Start
69706614/69312834 (Hg38)
End
69706713/69312933 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-let-7i/Upstream/39616; hsa-mir-1178/Downstream/271789;
Nearest TSS
ENST00000382841/Upstream/61659; ENST00000548839/Downstream/18949;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/72519, chr12-CpG: 57/Downstream/46792
Upstream sequence
CAGGTCAGGTGGATGCTGGGATCCAAGTAATTCTGATCTGAGGGAAGGAGGCGTGGCTGTGGCCTCAAGAGCACAGAGATGGTGGGAAGGTCCGTCACAG
Downstream sequence
caccactgctactgccactgccactgccactgccactaccacaaccacaaacttctatagcctaggccactgtgacattcagagttattgctgacattga
Target sequence
tgacaccaagagggatccccttggctaagtctccattgtggtgaaaatgagaataggaggaccccaaaagcccttgacagcaaggacattaacaaccta
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate