Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017077
Fusion event
HBV-ZNF618 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
Start
1038
End
1128
Integrated sequence
GTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAAGCAGGCTTTCACTTTCTCGCCAACTTACAAGGCCTTTCTGTGTAA
Host Sequence
Chromosome
chr9
Cytoband
q32
Reference genome
End
116740784/113978504 (Hg38)
Location type
Intron
Fragile sites / regions
Target gene
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-122-5p ; hsa-mir-760 ; hsa-mir-10a-5p ; hsa-mir-548s ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-513a-5p ; hsa-mir-3926 ; hsa-mir-1224-3p ; hsa-mir-942-3p ; hsa-mir-3591-3p ; hsa-mir-21-3p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-210-3p ; hsa-mir-518a-5p ; hsa-mir-527 ; hsa-mir-574-5p ; hsa-mir-6867-5p
Nearest miRNA
hsa-let-7a-1/Upstream/2046240; hsa-mir-12126/Downstream/230930;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/77211, chr9-CpG: 71/Downstream/70554
Upstream sequence
ATAAAAGATGCCTTCCCTGGCGAGCACATCAAGGTTTCAGTCGCTTGGCTGTGTCCTTGGGAATTTTCTTGAGTCCCCACTCCCAGGAGCCACATCAGAC
Downstream sequence
CATGTCGGTGTGACTTTTagcatctaaaatgtgcccagttctgtctgtatgctcaggaaacagcaaaaaacaagGGAGTATATTCCCTGTGTCTTGGGAC
Target sequence
ACACATCAGGGAGAGAGAGAGGCAGGTGGCAAGCGCAGAGCCCAGGCGCCTTTCTCTGTGGAAGAGGTGGGACCCTTCATTCCTTTCCTTTATTT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.