DUSP16 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017080
Fusion event
HBV-DUSP16 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1591
End
1679
Integrated sequence
TTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGC
Host Sequence
Chromosome
chr12
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
12634922/12481988 (Hg38)
End
12635019/12482085 (Hg38)
Location type
Intron
Target gene
DUSP16
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-192-5p ; hsa-mir-6818-5p ; hsa-mir-580-3p ; hsa-mir-4693-5p ; hsa-mir-4738-3p ; hsa-mir-892a ; hsa-mir-4318 ; hsa-mir-606
Nearest miRNA
hsa-mir-1244-3/Upstream/369952; hsa-let-7i/Downstream/282564;
Nearest TSS
ENST00000382841/Upstream/124570; ENST00000544086/Downstream/3268;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/124494, chr12-CpG: 111/Downstream/79614
Upstream sequence
AGCTATTTGGTTGGCACTACATAAAGAGCCCACCTTTGGTTTTATGGCTCCCGGAATCTGGCCCAGCCATCATAAGCCCAATGTATGTTTGTATTTTTTC
Downstream sequence
gagtctgggtTTTTGTTTTTTAATGTTGACAATACTCTCTCATTAATTTTAATAATTATCTATCTCAAAACCTAGATTATAAGGACCTAGAAGGATCTTG
Target sequence
ttgctcctttataccattataatgtgtatgtgtgagaatatgtgtatcttttggttctaacctattattgaaaactgcttcaaatccttactggaag
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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