Basic Information
VIS ID
TVIS10017082
Fusion event
HBV-chr13 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1821
End
1907
Integrated sequence
CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGAC
Host Sequence
Chromosome
chr13
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
54500268/53926133 (Hg38)
End
54500324/53926189 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-15a/Upstream/1115993; hsa-mir-1267/Downstream/385783;
Nearest TSS
ENST00000623511/Upstream/110714; ENST00000616396/Downstream/201154;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/723923, chr13-CpG: 25/Downstream/3214648
Upstream sequence
CACATCTTCTGAAAGCCTTCTATTCATTATTGCACTGTGTTATGGCTTTGTGTTAACTCCAAAGCTTAAGAAAATAAGTAGTATAGATATGCATTTTCCA
Downstream sequence
CAATTTTTAATGAGGGATACACAACTATCTATTGGTTATTGGTTACATTCAGGTCAGGGATAAGGGGACCAGGTAGTCATGCAGGAAATTAGCTTTCATT
Target sequence
accatttattaaagtatgaatTCGATCTATCTAATCATCTTATACAGAGGTATGTA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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