Basic Information
VIS ID
TVIS10017083
Fusion event
HBV-chr16 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1666
End
1758
Integrated sequence
CTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGG
Host Sequence
Chromosome
chr16
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
85976600/85942994 (Hg38)
End
85976700/85943094 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12128/Upstream/24578; hsa-mir-11401/Downstream/1891498;
Nearest TSS
ENST00000527434/Upstream/6771; ENST00000599411/Downstream/38656;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/43658, chr16-CpG: 24/Downstream/4952
Nearby gene
LINC02132(-6143) ; LOC105371388(+2385) ;
Upstream sequence
attccatttgatgatgattacattcgattccatttgacgattccatctgattctattcgaggattccatttgattccattcgatgatgattccattcgag
Downstream sequence
acctggcAGGAGCttttcttttctttttatttttttagagactgggtttttctgtgtcactcaggctggggtgcagtggtgatcacagctcactgcagcc
Target sequence
gagtttcaccatattggccaggctggtctcgaactcctgacctcatgatccgcccgcctcagcctcccaaagtgctgggattacaagcgtgagccaccac
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate