Basic Information
VIS ID
TVIS10017085
Fusion event
HBV-chr17 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1451
End
1543
Integrated sequence
GCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCG
Host Sequence
Chromosome
chr17
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
20721368/20818055 (Hg38)
End
20721467/20818154 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1180/Upstream/1473481; hsa-mir-10226/Downstream/6475756;
Nearest TSS
ENST00000595228/Upstream/29984; ENST00000578888/Downstream/37792;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/33455, chr17-CpG: 70/Downstream/22619
Upstream sequence
GGAGGTGGTGTCTATGTCAGGATTTCTGCCACTGAAAAAACAAAGTGTGTTGGATGACTGCAGATAAAGATTGGCAGACACAAGAAATCATAGACACCAA
Downstream sequence
ggcacacgcctgtaatcctagctactcaagaggctgaggcaggagtgttgcttgagcctgggaagtggaggttgcagtgagccgagatcacaccactgca
Target sequence
aggcaggcagatcacctgagaccaggagtttgagaccagcctggccaatatggtgaaatgccacctctactaaaattacaaaaattagccgggcatggt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate