Basic Information
VIS ID
TVIS10017086
Fusion event
HBV-NSFP1 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2338
End
2427
Integrated sequence
CTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGAT
Host Sequence
Chromosome
chr17
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
44498179/46420813 (Hg38)
End
44498272/46420906 (Hg38)
Location type
Intron
Target gene
NSFP1
Nearest miRNA
hsa-mir-1180/Upstream/945378; hsa-mir-10226/Downstream/552111;
Nearest TSS
ENST00000595228/Upstream/59016; ENST00000572638/Downstream/90605;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/47567, chr17-CpG: 71/Downstream/158218
Upstream sequence
TATACTCATAAAATCCAATTGTTGTAACAATAGATAGGTACCTTCTTCTGTTAGCAAGTAACTACAACTCACCTGCTTGTGTGCATGATCATAGGAGTTG
Downstream sequence
ttcctgcctctgcctcccgagtaactgggataacaggcatgcgccaccacacccgactaattttgtacttttagtagagatggggtttcaccatgttaat
Target sequence
ttttgagatggtgtgttaccctgtcatccaggctggagtgcagcggcaccatctcagctcactgcaacctccgctttctgggttcaagtgatt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate