Basic Information
VIS ID
TVIS10017088
Fusion event
HBV-chr4 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
274
End
355
Integrated sequence
ATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCC
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
29613/29613 (Hg38)
End
29704/29704 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Downstream/320453;
Nearest TSS
ENST00000502981/Downstream/23581;
Nearest CpG islands
None/Target, None/Upstream, chr4-CpG: 46/Downstream/23600
Upstream sequence
tggagtgcagtggtgcaatcttggttcaccacaacctcggttcaccacaacctctgcctcccaggttcaagcaattcacctgcctcagcctccctagtag
Downstream sequence
GCTTCTAAAAGACTTTTTAAGGAGCACGGTATTTTTCCATTTTGAAAAAAAATTGGCAAAATATCTTCTACTATAGATAGAAGGTAATTGGCTGAGGGTA
Target sequence
CAGAGTATTTTGCCAAAAGAAAATTTCTTAGATATGTGAAGTTCACTTTTTTCTTTTAGTGATTTTAATGTAATGAAATTGAAAACTCTGT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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