VISDB - VIS Detail

Expression analysis of TCGA samples

Basic Information

VIS ID

TVIS10017091

Fusion event

HBV-FOXO1 integration

Validated

No

Detection method

Capture-NGS platform

Data source

Curated

Sample type

Tumor

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2019

PubMed ID

30070724

Virus Sequence

Virus name

HBV

Subtype

C

Reference genome

NC_003977

Start

1878

End

1967

Integrated sequence

CTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGAC

Host Sequence

Chromosome

chr13

Cytoband

q14.11

Reference genome

GRCh37/hg19

Start

41137258/40563121 (Hg38)

End

41137357/40563220 (Hg38)

Location type

Intron

Target gene

FOXO1

miRNAs that regulate target gene

hsa-mir-182-5p ; hsa-mir-96-5p ; hsa-mir-27a-3p ; hsa-mir-186-5p ; hsa-mir-183-5p ; hsa-mir-153-3p ; hsa-mir-9-5p ; hsa-mir-223-3p ; hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-106b-3p ; hsa-mir-132-3p ; hsa-mir-196a-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-370-3p ; hsa-mir-107 ; hsa-mir-132-5p ; hsa-let-7c-3p ; hsa-mir-27b-3p ; hsa-mir-376a-3p ; hsa-mir-526a ; hsa-mir-523-5p ; hsa-mir-522-5p ; hsa-mir-520c-5p ; hsa-mir-519c-5p ; hsa-mir-519b-5p ; hsa-mir-519a-5p ; hsa-mir-518f-5p ; hsa-mir-518e-5p ; hsa-mir-518d-5p ; hsa-mir-1253 ; hsa-mir-1251-5p ; hsa-mir-517-5p ; hsa-mir-520g-5p ; hsa-mir-3123 ; hsa-mir-8087 ; hsa-mir-3925-5p ; hsa-mir-1271-5p ; hsa-mir-593-5p ; hsa-mir-935 ; hsa-mir-5000-5p ; hsa-mir-941 ; hsa-mir-3177-5p ; hsa-mir-324-5p ; hsa-mir-186-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-6715a-3p ; hsa-mir-4733-5p ; hsa-mir-34c-3p ; hsa-mir-499b-3p ; hsa-mir-499a-3p ; hsa-mir-562 ; hsa-mir-6809-3p ; hsa-mir-4753-3p ; hsa-mir-942-5p ; hsa-mir-130b-5p ; hsa-mir-4282 ; hsa-mir-9-3p ; hsa-mir-135b-5p ; hsa-mir-200c-3p ; hsa-mir-135a-5p ; hsa-mir-222-3p ; hsa-mir-339-3p ; hsa-mir-215-3p ; hsa-mir-486-5p ; hsa-mir-21-5p

Nearest miRNA

hsa-mir-2276/Upstream/898986; hsa-mir-1267/Downstream/164596;

Nearest TSS

ENST00000623511/Upstream/357; ENST00000417731/Downstream/47909;

Nearest CpG islands

None/Target, chr13-CpG: 551/Upstream/27510, chr13-CpG: 296/Downstream/101143

Nearest cancer related gene

FOXO1(OG, No orient, 0)

Upstream sequence

TTACTTTTAAAAGACGTTAAATATTCCATAGAAAATAATAGCTTCtgagatcattttaaactgtttagaacagtgcttggtgcatagcaaatgctacgtt

Downstream sequence

CCACTGCGCCTGAGCAGAGCCTCTGCACAGCAGGATGAGGCCTGGCTCCAACACAAACTGGGAGAGAAGTCTTCTCTCATTAAAAGGTGGTAGAAGAGAG

Target sequence

ACAAAAAGGCTCTGGCTGGATTTGTGGTCACCCAGGGGTGCAGCCACAGCGCCCACATCCTCATGCCATTGACATGGGACGCCCGGGCCCGAGTGCCAA

Reference

Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.