Basic Information
VIS ID
TVIS10017094
Fusion event
HBV-chr13 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1557
End
1648
Integrated sequence
TGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGG
Host Sequence
Chromosome
chr13
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
88959641/88307386 (Hg38)
End
88959741/88307486 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1297/Upstream/688646; hsa-mir-1267/Downstream/1923696;
Nearest TSS
ENST00000623511/Upstream/164519; ENST00000424165/Downstream/233378;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/629756, chr13-CpG: 41/Downstream/1055672
Upstream sequence
aacggaaggaaggaaagaaggaaggaaggaaggtaggaaggaagaaagtgagggaagggggcagggaggggagggagggaagaataaaagcaaaataaaa
Downstream sequence
GAGCAAATTATTACACTAAATGACCGAGAAAAGTAATAGACTTGTTGTTTGAAATTATATCATTATAAAATTAGGAAAAAAATGATGTGAATGAATATGA
Target sequence
TATACCAATGTTTTTTAACAGCAATTCTCTCACATTGCAATAAAGATGCAATGAGGTTCATATTAAGTGCATTTTTATTATGTTTCAGTGTAACATTTTG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate