Basic Information
VIS ID
TVIS10017095
Fusion event
HBV-chr19 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1754
End
1844
Integrated sequence
TTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATC
Host Sequence
Chromosome
chr19
Cytoband
p12
Reference genome
GRCh37/hg19
Start
20360936/20250127 (Hg38)
End
20361033/20250224 (Hg38)
Location type
Intronic
Target gene
LOC102724427 ; LOC105372310
Nearest miRNA
hsa-mir-10395/Upstream/814969; hsa-let-7e/Downstream/149048;
Nearest TSS
ENST00000633603/Upstream/11667; ENST00000598131/Downstream/71081;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/197829, chr19-CpG: 19/Downstream/832134
Upstream sequence
CCCTCTCCGGGATCGGCAGGACCTCGCCACAGAGGGTAGGTGGGGAGACTGGACAGCCATGTCAGGTTTGGGGATGACCCCACACTTGGGTGACATGCAC
Downstream sequence
GATCACCTGTCTGGAGCAAGGAAAAAAACCCTTGACTATGAAGAGACATGAGATGATTGCCAAACCCCCAAGTAGGTGTGAGTGAAAATGAATACAAGAG
Target sequence
GAGCACATTTAGTAATGTGCTTATAATTGGAGAATATGAGCAAGACTCATGTTATTTATTTTTAATAAAACAGGTATTGTTGTCCTAAGCCAGACCT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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