Basic Information
VIS ID
TVIS10017096
Fusion event
HBV-chr19 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
356
End
446
Integrated sequence
AACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTT
Host Sequence
Chromosome
chr19
Cytoband
p12
Reference genome
GRCh37/hg19
Start
20779739/20596933 (Hg38)
End
20779835/20597029 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-10395/Upstream/197579; hsa-let-7e/Downstream/14525671;
Nearest TSS
ENST00000633603/Upstream/31124; ENST00000598116/Downstream/14530;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/544635, chr19-CpG: 19/Downstream/485329
Upstream sequence
AGCCAAGTCAGGTGCTCAGGGGTTAGGTGGCAAGTGGGCTGGAGTGCTAGGTCCTAGAGCAACTTCATTTGGGGGCACCAGGAACCTGGCGCTGTGAGAA
Downstream sequence
aagactccatctcaaaaaataaaaacaaaaatttaaaaataaaaGAAATTAaaagctaattttcacaaaactttataaataaatccaacaaatatatcat
Target sequence
ctgggctggaaatgttgtgatctcggctcactgcaacctccacctcacgggttcaagcgagattgcgccactgcactccagcctgggtgacacagc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate