Basic Information
VIS ID
TVIS10017099
Fusion event
HBV-MIR663B integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1
End
67
Integrated sequence
ATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGG
Host Sequence
Chromosome
chr2
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
133017236/132259663 (Hg38)
End
133017295/132259722 (Hg38)
Location type
Promoter
Fragile sites / regions
FRA2S
Target gene
MIR663B
Nearest miRNA
hsa-mir-1285-2/Upstream/2583; hsa-mir-10b/Downstream/173989;
Nearest TSS
ENST00000437798/Upstream/1694; ENST00000622084/Downstream/34655;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1496, chr2-CpG: 79/Downstream/93021
Upstream sequence
GCTGGGAGGGACATGCAAAGCAGCTGGGTGGGAGCTGAGCTTCCAGCTGCAGAGACCACCTGCTTCTTCCTCTCTGCACTGAGCGTCCTGTGCCTCCCTG
Downstream sequence
cactgaacttgggagcggatctgttttccaaaCATGAGGTGACTCTCGCTTTGCAATGGATCACAAGGGGCTGGGCTTTCCAGAGTCGGCAGGCTAAAGA
Target sequence
ccactgtgcagaccgaatcagaatgaagagagtccttcgtcctatatgccacatccctc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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