Fusion event
HBV-MIR663B integration
Detection method
Capture-NGS platform
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
CTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACAT
End
133026289/132268716 (Hg38)
Nearest miRNA
hsa-mir-1285-2/Upstream/11561; hsa-mir-10b/Downstream/164995;
Upstream sequence
tagttggcccaccatatccatgggttccatacctatggattcaacaaaccacaatcaaaaatatttagaaaaaaaaaagaatggttatatctgtacctaa
Downstream sequence
AAATGTCAGTCAGCACGGAAAAGAatgtatgtatgtatgtatgtatgtatgtatgtatgtatgtatgtatgtatgtatttatttatagacagagtctcac
Target sequence
AGACCTCCCTCTGTGTCACCTCGACTTTCAATAACAGTGGCCGCTAGGTGATGCCCGAAGACAACCGATGCCTGC
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.