Basic Information
VIS ID
TVIS10017102
Fusion event
HBV-chr7 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1774
End
1822
Integrated sequence
CTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACT
Host Sequence
Chromosome
chr7
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
13122438/13082813 (Hg38)
End
13122537/13082912 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-339/Upstream/6015768; hsa-mir-10399/Downstream/5044308;
Nearest TSS
ENST00000635602/Upstream/280564; ENST00000443947/Downstream/18479;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/395190, chr7-CpG: 18/Downstream/906841
Upstream sequence
tcacgatgtcaggagatcgaaatcagcctgaccaagatgatgaagccccatctgtactaaaaatacaaaaattagccggacgtggtagcgtgcacctgta
Downstream sequence
TATACACATTTTTAATCTTCCTTAACAATGAGATATTCTCAGTAAGTGCAAATGTTTATTCTGAAATTGTAGAAAAAAATTTATTATGTGGTTTTCATAA
Target sequence
ATGCACTGAGGACAGGGTGCCAGGCCTAGTCTTCTGACGTTCATCAGGGTGTTGCCCTGTTTGCTGTATTTGAGTGATTACTAGTCTATTTTAAGTTAA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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