Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017108
Fusion event
HBV-LIPA integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
Start
2027
End
2116
Integrated sequence
AGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGT
Host Sequence
Chromosome
chr10
Cytoband
q23.31
Reference genome
Start
End
91111617/89351860 (Hg38)
Location type
Intron
Fragile sites / regions
Target gene
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-744-5p ; hsa-mir-125b-5p ; hsa-mir-6083 ; hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-4473 ; hsa-mir-4671-3p ; hsa-mir-3944-5p ; hsa-mir-4660 ; hsa-mir-2115-3p ; hsa-mir-3074-3p ; hsa-mir-454-3p ; hsa-mir-3666 ; hsa-mir-4295 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-4676-3p ; hsa-mir-892c-3p ; hsa-mir-452-5p ; hsa-mir-944 ; hsa-mir-8054 ; hsa-mir-548l ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-101-5p ; hsa-mir-1250-3p ; hsa-mir-1285-3p ; hsa-mir-153-5p ; hsa-mir-3187-5p ; hsa-mir-382-3p ; hsa-mir-3945 ; hsa-mir-3973 ; hsa-mir-4253 ; hsa-mir-5189-5p ; hsa-mir-520g-3p ; hsa-mir-520h ; hsa-mir-548at-5p ; hsa-mir-578 ; hsa-mir-612 ; hsa-mir-676-5p ; hsa-mir-6860 ; hsa-mir-6862-5p
Nearest miRNA
hsa-mir-1265/Upstream/288353; hsa-mir-107/Downstream/240887;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/99657, chr10-CpG: 76/Downstream/62788
Upstream sequence
TGTTAACACGGGTTCTAGAATGCAATTTTTAAAAATGTTTTGTGAATGACTAGCAACATGGTAATTTAATTTTCAAATATAATTTACAAGTGAAATGTGT
Downstream sequence
tagcaactaaaaattgatttttcaaactcagtgtgtctccatctggagaCAACGTCtgagaaataaaaataaaatcctaagccccacaagcaactgaaca
Target sequence
cttagagtcttaattgacccactcaaaaaatacgcgcatcaccctggaacatcatcagccttaaagattcagacatctgacatcacaagggctctc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.