TECTB _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017109
Fusion event
HBV-TECTB integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2645
End
2735
Integrated sequence
CCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCA
Host Sequence
Chromosome
chr10
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
114041512/112281754 (Hg38)
End
114041599/112281841 (Hg38)
Location type
Promoter
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
TECTB
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-107/Upstream/1292741; hsa-mir-202/Downstream/17771;
Nearest TSS
ENST00000439456/Upstream/66377; ENST00000643850/Downstream/1559;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/97855, chr10-CpG: 58/Downstream/165005
Upstream sequence
ACACTCTTAGTGACTGTCAAAGTTCCTGAGTCATTAGGTGCCTGCAGACTATGCCCACTGATATTTGCATTAGGTGCAGGCTGCCTAGCTGTGCTGACAC
Downstream sequence
gaaaccatcattctcagcaaactaacacaagaacagaaaaccaaacactgcatgttttcactcataagtgggagttgaacaatgagaacacatggacaca
Target sequence
aaaatgtgacacatatacaccatggaatactatgcagccataaaaaaggatgagttcatgtcctttgcagggacatggatgacgctg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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