Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017114
Fusion event
HBV-CCNA2 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
Start
1125
End
1214
Integrated sequence
GTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCT
Host Sequence
Chromosome
chr4
Cytoband
q27
Reference genome
End
122745780/121824625 (Hg38)
Location type
Exon
Target gene
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-let-7b-5p ; hsa-mir-146a-5p ; hsa-mir-193b-3p ; hsa-mir-132-3p ; hsa-mir-212-3p ; hsa-mir-98-5p ; hsa-mir-197-3p ; hsa-mir-10b-3p ; hsa-mir-130b-3p ; hsa-mir-27b-3p ; hsa-mir-548aw ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-1825 ; hsa-mir-4676-5p ; hsa-mir-575 ; hsa-mir-548e-5p ; hsa-mir-148a-3p ; hsa-mir-152-3p ; hsa-mir-148b-3p ; hsa-mir-4295 ; hsa-mir-130a-3p ; hsa-mir-301b-3p ; hsa-mir-3666 ; hsa-mir-454-3p ; hsa-mir-301a-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-6835-3p ; hsa-mir-29c-3p ; hsa-mir-29a-3p ; hsa-mir-29b-3p ; hsa-mir-22-3p
Nearest miRNA
hsa-mir-12113/Upstream/7167681; hsa-mir-1305/Downstream/3682634;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/423, chr4-CpG: 50/Downstream/45420
Upstream sequence
tgaaaggacctcttttgggGGTCCtttatccttaatccactgcaccctagcctctccccctagcaaactgctgaaatgccactgttatgagtcaccaatg
Downstream sequence
CTGTGGCAACCAACAAAAAACACAATGACGTTCTAGTGACCTAGATATAATTATGTTCCTTTCAGAAGTAAAGTTTTTTAAACATAGTAAAAACAATATG
Target sequence
CCTTGAACTACTGTTGATATATATAATAAATAGCAGTGCATTACAAAATATTCAAATACAGTCATTAATTTTTTTCTATTTTTCCCCAAG
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.