Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017116
Fusion event
HBV-IQSEC1 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
Start
1489
End
1581
Integrated sequence
TCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGT
Host Sequence
Chromosome
chr3
Cytoband
p25.2
Reference genome
Start
End
12961982/12920482 (Hg38)
Location type
Intron
Target gene
miRNAs that regulate target gene
hsa-mir-92a-1-5p ; hsa-mir-589-3p ; hsa-mir-378a-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-2355-3p ; hsa-mir-676-3p ; hsa-mir-6749-3p ; hsa-mir-642a-5p ; hsa-mir-6721-5p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-3616-3p ; hsa-mir-3655 ; hsa-mir-4469 ; hsa-mir-1914-5p ; hsa-mir-5193 ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-4650-5p ; hsa-mir-7843-5p ; hsa-mir-6735-5p ; hsa-mir-6879-5p ; hsa-mir-4632-5p ; hsa-mir-4436b-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-12127/Upstream/2525837; hsa-let-7g/Downstream/2575757;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/11874, chr3-CpG: 87/Downstream/14984
Upstream sequence
GCCTGTCTTATTCTTGCTTTTAAACAAAGGCAATTTCTTATTTGCTTTGCAAAGACATATGACTATTTCAAAATCACGTGAGACTTTTGCTGCAGACAAG
Downstream sequence
TTGGGGCTGTACATGTCGGTGTTCAGCAGGATGATGGCGAAGGCCAGGATGAAAATGGTGTCTGGGTTCCGGAATTGCCGCACCACCCCAGGGTTGCAGA
Target sequence
GTGGCTGGCCGACCGCCTGAGACAGCTCACCTCGGAGGTTCTTGATGAAGTCCTCTAGCTTCATTTTCCGCTCGGGCTTGACA
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.