Fusion event
HBV-TERT integration
Detection method
Capture-NGS platform
Disease
Hepatocellular carcinoma (HCC)
Integrated sequence
ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGA
End
1295774/1295659 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-4635/Upstream/232598; hsa-mir-10397/Downstream/13651;
Nearest cancer related gene
Upstream sequence
agtagttgggactacaggtatgtgccaccacgcctggctaatttttgtatctttagtagagacagggtttcatcatggtggccagactggtttcaaactc
Downstream sequence
GTGCCTCCCTGCAACACTTCCCCGCGACTTGGGCTCCTTGACACAGGCCCGTCATTTCTCTTTGCAGGTTCTCAGGCGGCGAGGGGTCCCCACCATGAGC
Target sequence
GAAGGGGAGGACGGAGGCGCGTAGACGCGGCTGGGGACGAACCCGAGGACGCATTGCTCCCTGGACGGGCACGCGGGACCTCCCGGA
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.