PRPF31 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017122
Fusion event
HBV-PRPF31 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1897
End
1987
Integrated sequence
GGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGA
Host Sequence
Chromosome
chr5
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
104045697/104709996 (Hg38)
End
104045796/104710095 (Hg38)
Location type
Intron
Fragile sites / regions
FRA5F
Target gene
PRPF31
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-10397/Upstream/3893431; hsa-mir-103a-1/Downstream/5803734;
Nearest TSS
ENST00000502646/Upstream/630085; ENST00000523745/Downstream/29446;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/1450147, chr5-CpG: 253/Downstream/2959334
Upstream sequence
GGGCGGTCCCGTCGAGAAAGGGTGGGAAATGGAGCCAGGCGCTCCTGCTGGCCGCGCACCGGGCGCCTCACACCAGCCACAACGGCCTTGACCCTGGGCC
Downstream sequence
tcatccaacagacccctctctctttaactttctccccacctgcctgttgagagtgcatgtcccagaaagcagccccccttcctgctggacctgcaaggta
Target sequence
agtgtgtctccaaggatctcatacctactcgttcaaaacccaattaaaattccctgaggaaagcctgcttgggtaatgcttggaaccccaacaaaggct
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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