Basic Information
VIS ID
TVIS10017123
Fusion event
HBV-LOC101928391 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1555
End
1646
Integrated sequence
TGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAA
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
27382118/27055627 (Hg38)
End
27382217/27055726 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
LOC101928391
Nearest miRNA
hsa-mir-12136/Upstream/501034; hsa-mir-101-1/Downstream/3683430;
Nearest TSS
ENST00000473358/Upstream/42791; ENST00000472249/Downstream/43956;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/42677, chr1-CpG: 39/Downstream/99128
Upstream sequence
TGAACCCTTACTTTTACTACACAAAACTTAACTGGGAATAATGTCCATATATCTTTCTTTAGCATAGTACATACTCTACtaaataaaatatttaaataaa
Downstream sequence
gacagagtgagaccctgtttcaaaaaaaaaaaaaacagagacagaagaGTGAGGTGGGAAAATACCCAATCCTTTGgcacgtatcacttcgattcatatt
Target sequence
gtcccagctactccggaggctgaggtaggaggattgcttgagtccaggaggtggaggttgcagtgagctgtgatcacaccattgcaccccagcctgggt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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