Basic Information
VIS ID
TVIS10017124
Fusion event
HBV-LOC101928391 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1861
End
1951
Integrated sequence
CTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTC
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
27389289/27062798 (Hg38)
End
27389389/27062898 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
LOC101928391
Nearest miRNA
hsa-mir-12136/Upstream/508205; hsa-mir-101-1/Downstream/3676258;
Nearest TSS
ENST00000473358/Upstream/49962; ENST00000472249/Downstream/36784;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/49848, chr1-CpG: 39/Downstream/91956
Upstream sequence
atggattttaaggaacaactaatacggctttctaatgggttagatatgggctgtaaacaaaaaaaatgagttcactacagatttttagtttcaacaactc
Downstream sequence
gcaggctagcgtccggactcTCAGCTATGTACCAGGCTGCTTTTCTGGAAATGTTTTCCAGTTCCCCCGTGGGTGAAAGGCCTGTCCTTCCCACACCTTC
Target sequence
GGGTAGATAGTGCAGTggcagcatcctaagggctttatgtgacctgtatgaactcatttaatccccactggcttggccaaggccacagagctgaagagtg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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