Basic Information
VIS ID
TVIS10017128
Fusion event
HBV-chr20 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
2429
End
2520
Integrated sequence
TCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAAT
Host Sequence
Chromosome
chr20
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
49014391/50397854 (Hg38)
End
49014491/50397954 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/533901; hsa-mir-1-1/Downstream/187832;
Nearest TSS
ENST00000382410/Upstream/76512; ENST00000541713/Downstream/112367;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/54018, chr20-CpG: 84/Downstream/112126
Upstream sequence
agcaaggatagagctgaaacacagatgcctaagggaaggacgccagacctggaagaggacaaacggggtgatcttgcttacataaagctcgaaaacaggc
Downstream sequence
ttgggaagaacttgttgtactatttccaccgtgggatatggcatatgatatgatacaacacaacagacgtcaatcacttcaacaacacagagaacagtga
Target sequence
caagggggagccctgatttttacatgtatccatttcggtggtgtaaatagtcccaccatggtccatttggagctaccagtgtgacttactgagcatggca
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate