PRPF31 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017132
Fusion event
HBV-PRPF31 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
155
End
246
Integrated sequence
CATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGA
Host Sequence
Chromosome
chr6
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
143294083/142972946 (Hg38)
End
143294179/142973042 (Hg38)
Location type
Intron
Target gene
PRPF31
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-10398/Upstream/2289063; hsa-mir-1202/Downstream/8129633;
Nearest TSS
ENST00000381078/Upstream/16248; ENST00000367596/Downstream/48911;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/25292, chr6-CpG: 84/Downstream/87265
Upstream sequence
CTAAGTACTGTGTGCTAAGTTTGACAGTCCATCCTGTGCTCACTATTCTAAATATCGCAGCATTAATTCAGGCTTTCATTGTTTTTTCGCTTGAATATTA
Downstream sequence
gtgatgggtgcactaaaatctcagaatatactactatagaacttatttgagtaaccaaaaccacctgtaccccaaaagctattgaaataaaaaaaATTCC
Target sequence
gagtgatataaaggactatgggaacttgtggtggggaggttgggaggaaggtgagagataagagactgcatattggatacagtgtacaccgttagg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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