Basic Information
VIS ID
TVIS10017134
Fusion event
HBV-chr9 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
114
End
204
Integrated sequence
TTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGG
Host Sequence
Chromosome
chr9
Cytoband
q34.11
Reference genome
GRCh37/hg19
Start
132141356/129379077 (Hg38)
End
132141451/129379172 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-let-7a-1/Upstream/986363; hsa-mir-12126/Downstream/490433;
Nearest TSS
ENST00000422679/Upstream/37234; ENST00000439014/Downstream/59044;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/26653, chr9-CpG: 67/Downstream/4125
Nearby gene
RN7SL159P(-8616) ;
Upstream sequence
TTCCTCTAGATGGAAGGGATGGATGATGACCCCGAAGACCGCATGTCCTACTTAACCGCCATGGGCGCGGACTATCTGAGTTGCGACAGCCGCCTCATCA
Downstream sequence
GTCTGAGCCTCACCCCAGCCTCTTCTTTCCTGGCCAGATCCCTTCCCGACATGTCATGTGCCCAAACCCTGGACCCCTCACTCCTGCTCATTCCGGCAGC
Target sequence
CTCCCTCAGGAGCTCACAGTGGGTGCAGGGGGTGGAAAAGGAATGCTCCTGGGCCTATCGGGTCAGTAAACCCAGACTCTACATTTGCTAGGCCT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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