Basic Information
VIS ID
TVIS10017141
Fusion event
HBV-chr3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1622
End
1735
Integrated sequence
TGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGG
Host Sequence
Chromosome
chr3
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
170702075/170984286 (Hg38)
End
170702193/170984404 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/561124; hsa-mir-1224/Downstream/122260;
Nearest TSS
ENST00000440867/Upstream/75593; ENST00000467896/Downstream/23066;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/75234, chr3-CpG: 20/Downstream/43879
Upstream sequence
CTCAGCTCCACTTAAGGTGATAGAACTTGTGCTAGCTGTTTCCAAAGCAAAATGTGAGAAGACAGGAGTCCCAAGATAATACTTCCAAATCATTAGGTCT
Downstream sequence
tattccatttcattggccaatgtgtctggttttatgccagtaccatgctgttttgattactgtagctttttaatatgttttgaaatgtattagtatgatg
Target sequence
ctgtgtctggccccatcatttatttattgacgagactatcctttcaccattgtatgtttctggtacctctgttgaaaatcaattgactattgatgtgtgggtttatttctgggttctg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate