Basic Information
VIS ID
TVIS10017142
Fusion event
HBV-chr3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
C
Reference genome
NC_003977
Start
1275
End
1370
Integrated sequence
CGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGT
Host Sequence
Chromosome
chr3
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
170759596/171041807 (Hg38)
End
170759699/171041910 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/618645; hsa-mir-1224/Downstream/64754;
Nearest TSS
ENST00000440867/Upstream/15057; ENST00000467896/Downstream/22132;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/13304, chr3-CpG: 89/Downstream/418130
Upstream sequence
TGCTCCTCACTCCCCACTGCTTCTCACTCCCTACTGTGCTGGCCCTGCTCCTTTCTGCGTGGGCTCCCTGAGCCTGGCCCACACCCCTCTAAATAGCACT
Downstream sequence
agatggggttttaccgatggtctcaatctcctgacctcatgatctgcctgcctcggcctcccaaaatgctgggattacaggtgtgggccttccaaagtgc
Target sequence
tccgcttcccaggttcaagtgattctcctgcctcagcctcccgagtagctaggactacaggcatgtgccaccatgcctggctaattttttatagttttagtag
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
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