Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017145
Fusion event
HBV-IQSEC3 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
Start
2896
End
3009
Integrated sequence
CCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCT
Host Sequence
Chromosome
chr12
Cytoband
p13.33
Reference genome
Start
End
231785/122619 (Hg38)
Location type
Intron
Target gene
miRNAs that regulate target gene
hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-625-5p ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-6883-5p ; hsa-mir-6799-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-6775-3p ; hsa-mir-1291 ; hsa-mir-765 ; hsa-mir-4533 ; hsa-mir-5008-5p ; hsa-mir-3192-5p ; hsa-mir-4292 ; hsa-mir-6791-5p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-4779 ; hsa-mir-8080 ; hsa-mir-8485 ; hsa-mir-548ad-3p
Nearest miRNA
hsa-let-7i/Downstream/1537696;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/17441, chr12-CpG: 99/Downstream/15670
Upstream sequence
GGTGCTCATTAATCTTCTTTATGCTCTAGATGACAGAAAGCTATTGACTATTGTGTTGCAGACCAGAGACCTAGATGCAGAAAGACAGAAGGGCATAGGC
Downstream sequence
actgctttgggccactggggctcgatcccactggggacttagggagatggtatagggtgtgcctcagagttgtcccgtgcaagggacagggaagctgggg
Target sequence
TTTTATCAcaagtagtttatttgggacaaggtgaccccaggaaagggctgtagaggagtagggaaatgaaacacagaagagaatgaagccatggcagagttcattaattatcaagtg
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.