Basic Information
VIS ID
TVIS10017146
Fusion event
HBV-chr14 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
2871
End
2980
Integrated sequence
GCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCC
Host Sequence
Chromosome
chr14
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
47132428/46663225 (Hg38)
End
47132544/46663341 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/9710834; hsa-mir-1185-1/Downstream/1097654;
Nearest TSS
ENST00000550708/Upstream/11404; ENST00000557531/Downstream/218881;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/11269, chr14-CpG: 186/Downstream/1010889
Nearby gene
LOC105370481(-2876) ;
Upstream sequence
acagagacagagacagagtaacagagaaagacagagagacagagacacagagacagagacagagtaacagagaaagacagagagacagagagagacagag
Downstream sequence
atgtgtgtgtgtatatatatatatatatatatatatatatatatatatatatatataGGCACATATTTTAAATTGTATTTTACTTTCACATTTACACATT
Target sequence
ttagcttagagatctgctaatgattggaatgactggacagatattttcttaattgctttgagccaatatgctttccactcttggctgaagggatttatgtgtctgtGTGTGtatgt
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate