PRPF31 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10017147
Fusion event
HBV-PRPF31 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
1703
End
1799
Integrated sequence
CATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGT
Host Sequence
Chromosome
chr15
Cytoband
q14
Reference genome
GRCh37/hg19
Start
36336876/36044675 (Hg38)
End
36336964/36044763 (Hg38)
Location type
Intron
Target gene
PRPF31
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-383-3p
Nearest miRNA
hsa-mir-1233-1/Upstream/117752; hsa-mir-10393/Downstream/928058;
Nearest TSS
ENST00000557528/Upstream/69906; ENST00000560056/Downstream/1319;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/498361, chr15-CpG: 35/Downstream/534495
Upstream sequence
AAAAAGAACCAGACGAATGAAATCAATACTGCTAATGTTACTGATATCTACAACTATTACACCGACAAAGTACCTTTGGAATGTAATTGGCAAACTGGAT
Downstream sequence
GAATTTTCTATTTTCCAAAACACTGATGACTTCAAAATATTCTCAAAAATGAAATCAACTTTGACTGAAATCATTTCAATTTTCATTGAATAAATTAACA
Target sequence
TGTACCTAATCTTCATGTTGGTTTGAGAGATACTGTCATACCATTTTACAGTTAAGAAAGAAACAGTAATTTTAACTCACATTAAGGT
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate