Basic Information
VIS ID
TVIS10017149
Fusion event
HBV-chr16 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
861
End
972
Integrated sequence
GTTACTCTCTAAATTTTATGGGTTATGTCATTGGATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCC
Host Sequence
Chromosome
chr16
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
46414400/46397319 (Hg38)
End
46414484/46397403 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/12233646; hsa-mir-11401/Downstream/3895213;
Nearest TSS
ENST00000527434/Upstream/10610432; ENST00000569239/Downstream/186850;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/10294606, chr16-CpG: 124/Downstream/30055
Upstream sequence
aagctcaacatcactgatcattagagaaatgcaagtcaataccacaatgagataccatctcatgccagtcagaatggcgattattaaaaagtgaagaaac
Downstream sequence
tcgatgatgattccattcgagtccattcaatgattccattggattccgtttgataattattccattagagttcattcgatgattcccttcgagtccattc
Target sequence
attcgtgtccattcggtgatttcattagattccattcgaggatgattccattccattccattcgatgattccattcaattccat
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate