Basic Information
VIS ID
TVIS10017151
Fusion event
HBV-chr4 integration
Validated
No
Detection method
Capture-NGS platform
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2019
PubMed ID
30070724
Virus Sequence
Virus name
HBV
Subtype
B
Reference genome
NC_003977
Start
3010
End
3115
Integrated sequence
GGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAG
Host Sequence
Chromosome
chr4
Cytoband
p11
Reference genome
GRCh37/hg19
Start
49112770/49110753 (Hg38)
End
49112859/49110842 (Hg38)
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/1458010; hsa-mir-1243/Downstream/3601840;
Nearest TSS
ENST00000502981/Upstream/82061; ENST00000504661/Downstream/2732158;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/123962, chr4-CpG: 24/Downstream/50598
Upstream sequence
agcactttgggaagctgaggtggaactcctggctcacttgagtccaggagctcaagaccagcctgtgcaacatagtgagaccctgtcttaaaaaaaaaaa
Downstream sequence
attcctttcaatttcattctattccattccattccattccattccattctattccattccactcgggttgattccataccattctattccattccattcc
Target sequence
ttccattccattccattccattcgggttcattccattccattccattccattccattccattccattccactcgtgttgtttccattcc
Reference
Li, C. L., et al.Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter Region. Hepatology,2019, 69(2): 498-512.
Curate